Key result
Coupled 3D-0D computational modeling improves simulated cardiocirculatory hemodynamics across hypertensive states over standalone 0D models.
Why the study?
Patient-specific cardiocirculatory models for hypertension are needed to develop digital twins that provide refined and clinically meaningful insights beyond existing models.
Advanced 3D-0D electromechanical computational models accurately simulate hypertension hemodynamics, providing a foundational step toward patient-specific digital twins for cardiovascular monitoring.
Should not yet alter hypertension management; extends computational modeling toward patient-specific digital twins.
In this work, we develop patient-specific cardiocirculatory models with the aim of building digital twins for hypertension. In particular, in our pathophysiology-based framework, we consider both 0D cardiocirculatory models and a 3D-0D electromechanical model. The 0D model, which consists of an RLC circuit, is studied in two variants, with and without capillaries. The 3D–0D model consists of a three-dimensional electromechanical model of the left ventricle, coupled with a 0D model for the external blood circulation: this representation enables the assessment of additional quantities related to ventricular deformation and stress, and offers a more detailed representation compared to a fully 0D model. Sensitivity analysis is performed on the 0D model, with both a mono- and a multi-parametric approach, in order to identify the parameters that most influence the model outputs and guide the calibration process. We studied three different scenarios, corresponding to systemic, pulmonary and renovascular hypertension, each in three nuances of severity. To maintain a fair comparison among the models, a parameter calibration strategy is developed; the outputs of the 0D model with capillaries are utilized to indirectly calibrate the 3D–0D model parameters. The results demonstrate that the 3D–0D model yields a realistic representation of cardiocirculatory dynamics in the presence of hypertension; this model represents a powerful step toward digital twins for real-time hypertension control, providing refined and clinically meaningful insights beyond those achievable with 0D models alone.
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Celora et al. (2026) studied Hypertension. 3D-0D electromechanical computational model vs. 0D cardiocirculatory models alone was evaluated. The 3D-0D computational model yielded a realistic representation of cardiocirculatory dynamics in systemic, pulmonary, and renovascular hypertension compared to fully 0D models alone.
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