3′,4′-Dihydronorstephasubine, a New Bisbenzylisoquinoline from the Bark of Alseodaphne corneri

A new bisbenzylisoquinoline, 3 ,4 -dihydronorstephasubine (1) together with two known alkaloids, norstephasubine (2) and gyrolidine (3) were isolated from the stem bark of Alseodaphne corneri (Lauraceae).The 13 C-NMR data for norstephasubine (2) and gyrolidine (3) were also reported.Structural elucidation of 1 was performed by spectral methods such as 1D-and 2D-NMR, IR, UV, and HRMS. 3 ,4 -Dihydronorstephasubine (1) and gyrolidine (3) showed moderate vasorelaxant effect on rat aorta.Alseodaphne corneri belongs to the family of Lauraceae.[11] Recently we have isolated three new bisbenzylisoquinoline alkaloids, -oxoperakensimines A -C, showing vasorelaxant activity from the bark of Alseodaphne perakensis. 12Our continued effort on identifying additional new alkaloids with biological activities from A. corneri led to the isolation of a new bisbenzyisoquinoline, 3 ,4 -dihydronorstephasubine (1) and two known alkaloids, norstephasubine (2) and