Signifificance of Molecular Pathology in Unexplained Sudden Cardiac Deaths: Epigenetics of Cardiomyopathies

Cardiomyopathy, a prominent cause of lethal ventricular arrhythmias and heart failure, may be defined as a primary weakness of the myocardium, impaired myocardial perfusion, or an infiltrative process. Cardiomyopathies are not random in the general population, particularly hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and dilated cardiomyopathy are ought to be kept in mind, occasionally, when investigating sudden deaths of young adults. Cardiomyopathies are associated with multiple genetic and modifiable risk factors; however, given environmental and genetic influences yet to explain precise pathophysiology. Epigenetic mechanisms would endeavour to address some of the gaps in our current knowledge regarding the interaction between nature and nurture in the development of cardiomyopathies.