What question did this study set out to answer?

To determine the impact of increasing dialysate magnesium concentrations from 0.50 to 0.75 mmol/L on arterial stiffness, hemodynamics, and long-term mineral metabolism in maintenance hemodialysis patients.

September 29, 2020Advances in TherapyOpen Access

Consequences of Supraphysiological Dialysate Magnesium on Arterial Stiffness, Hemodynamic Profile, and Endothelial Function in Hemodialysis: A Randomized Crossover Study Followed by a Non-Controlled Follow-Up Phase

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Authors

RGRosaria Del GiornoEnte Ospedaliero Cantonale SHSoraya HadjeresEnte Ospedaliero Cantonale KSKevyn StefanelliUniversità degli Studi della Tuscia

Discussion

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Implication

Randomized crossover trial reveals that higher dialysate magnesium reduces arterial stiffness and blood pressure in hemodialysis patients, indicating potential cardiovascular benefits.

Key Points

To determine the impact of increasing dialysate magnesium concentrations from 0.50 to 0.75 mmol/L on arterial stiffness, hemodynamics, and long-term mineral metabolism in maintenance hemodialysis patients.
Conducted a randomized 4-week crossover trial comparing 0.75 mmol/L against standard 0.50 mmol/L dialysate magnesium, followed by an uncontrolled 6-month extension phase (N=39 analyzed; ISRCTN 74139255).
Evaluated pulse wave velocity, pulse pressure, systolic blood pressure, endothelial function, and mineral metabolism markers using linear mixed models for repeated measures.
Higher dialysate magnesium significantly lowered pulse wave velocity by −0.91 m/s (95% CI −1.52 to −0.29; p = 0.01), pulse pressure by −9.61 mmHg (95% CI −18.89 to −0.33; p = 0.04), and systolic blood pressure by −12.96 mmHg (95% CI −24.71 to −1.22; p = 0.03).
At 6-month follow-up, higher dialysate magnesium increased ionized magnesium from 0.54 to 0.64 mmol/L (+21%, p ≤ 0.001) and total serum magnesium from 0.84 to 1.07 mmol/L (+27%, p ≤ 0.001), while parathormone decreased from 36.6 to 34.4 pmol/L (−11%, p = 0.03).

Cite This Study

Giorno et al. (2020) studied this question.

synapsesocial.com/papers/6a74624284fffe492cdbd0dd https://doi.org/10.1007/s12325-020-01505-9

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September 29, 2020Advances in TherapyOpen Access

Consequences of Supraphysiological Dialysate Magnesium on Arterial Stiffness, Hemodynamic Profile, and Endothelial Function in Hemodialysis: A Randomized Crossover Study Followed by a Non-Controlled Follow-Up Phase

View Full Paper

Ask AI

Bookmark

Authors

RGRosaria Del GiornoEnte Ospedaliero Cantonale SHSoraya HadjeresEnte Ospedaliero Cantonale KSKevyn StefanelliUniversità degli Studi della Tuscia

Discussion

Member takes

Implication

Randomized crossover trial reveals that higher dialysate magnesium reduces arterial stiffness and blood pressure in hemodialysis patients, indicating potential cardiovascular benefits.

Key Points

To determine the impact of increasing dialysate magnesium concentrations from 0.50 to 0.75 mmol/L on arterial stiffness, hemodynamics, and long-term mineral metabolism in maintenance hemodialysis patients.
Conducted a randomized 4-week crossover trial comparing 0.75 mmol/L against standard 0.50 mmol/L dialysate magnesium, followed by an uncontrolled 6-month extension phase (N=39 analyzed; ISRCTN 74139255).
Evaluated pulse wave velocity, pulse pressure, systolic blood pressure, endothelial function, and mineral metabolism markers using linear mixed models for repeated measures.
Higher dialysate magnesium significantly lowered pulse wave velocity by −0.91 m/s (95% CI −1.52 to −0.29; p = 0.01), pulse pressure by −9.61 mmHg (95% CI −18.89 to −0.33; p = 0.04), and systolic blood pressure by −12.96 mmHg (95% CI −24.71 to −1.22; p = 0.03).
At 6-month follow-up, higher dialysate magnesium increased ionized magnesium from 0.54 to 0.64 mmol/L (+21%, p ≤ 0.001) and total serum magnesium from 0.84 to 1.07 mmol/L (+27%, p ≤ 0.001), while parathormone decreased from 36.6 to 34.4 pmol/L (−11%, p = 0.03).

Cite This Study

Giorno et al. (2020) studied this question.

synapsesocial.com/papers/6a74624284fffe492cdbd0dd https://doi.org/10.1007/s12325-020-01505-9

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