April 1, 1990Journal of NeuroscienceOpen Access

A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila

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Population

Drosophila melanogaster mature third instar larvae, n=281 fibers.

Comparison

Genetic mutations, heterozygosity, and… vs Normal (wild-type) Sh+ larvae

Design

Preclinical

Authors

FHFN HauglandUniversity of Iowa CWCF WuAnhui Transport Consulting & Design Institute (China)

Discussion

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Implication

Highlights non-linear Sh dosage effects in Drosophila muscle; leaves open relevance to human cardiac channelopathies.

Structured PICO

Population

Drosophila melanogaster mature third instar larvae (normal Canton-S strain and various Shaker mutants including ShKs133, Sh102, ShM, Sh5, ShKO120, ShE62, ShKa2a, and aneuploids), n=281 fibers.

Intervention

Genetic mutations, heterozygosity, and aneuploidy of the Shaker (Sh) locus

Comparator

Normal (wild-type) Sh+ larvae

Outcome

Transient potassium current (IA) amplitude, kinetics, and voltage dependence measured via two-microelectrode voltage-clampsurrogate

The Shaker locus encodes the entire IA channel in Drosophila larval muscle, with evidence of interactions among protein subunits in heteromultimeric arrangements.

Cite This Study

Haugland et al. (1990) studied this question.

synapsesocial.com/papers/6a7463bcc64913a07da7fdf5 https://doi.org/10.1523/jneurosci.10-04-01357.1990

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A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider