Key result
A single 1 mg intravenous dose of vitamin K significantly reduced the time for INR reversal to <1.5 by a mean of 52 hours compared to stopping warfarin alone (P<0.05).
Why the study?
Does a single 1 mg intravenous dose of vitamin K reduce the time for INR reversal and pre-operative delay to surgery in hip fracture patients on long-term warfarin?
Observational
Does a single 1 mg intravenous dose of vitamin K reduce the time for INR reversal and pre-operative delay to surgery in hip fracture patients on long-term warfarin?
Mean Difference: 52
p-value: p=< 0.05
A single 1 mg intravenous dose of vitamin K significantly reduces the time for INR reversal and pre-operative delay to surgery in hip fracture patients on long-term warfarin.
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May shorten pre-operative delay in warfarinized hip fracture patients; leaves open need for RCTs before routine adoption.
Bhatia et al. (2010) conducted an observational in Hip fracture requiring surgery in patients on warfarin. Intravenous Vitamin K vs. Stopping warfarin alone (current practice) was evaluated on Time for INR to drop to 1.5 or below (MD 52 hours, p=< 0.05). A single 1 mg intravenous dose of vitamin K significantly reduced the time for INR reversal to <1.5 by a mean of 52 hours compared to stopping warfarin alone (P<0.05).
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