Key result
In intact rabbit ventricular myocytes, Na:Ca exchange stoichiometry is near 3:1 but affected by local ion gradients, and cytosolic Ca-dependent NCX regulation is a dynamic process.
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No immediate change to NCX targeting in patients; extends rabbit myocyte stoichiometry and regulation data but leaves open human translation.
Bers et al. (2007) studied this question. Na:Ca exchange stoichiometry and cytosolic Ca-dependent regulation was evaluated on Na:Ca exchange stoichiometry and cytosolic Ca-dependent regulation. In intact rabbit ventricular myocytes, Na:Ca exchange stoichiometry is near 3:1 but affected by local ion gradients, and cytosolic Ca-dependent NCX regulation is a dynamic process.
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