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November 1, 1989Journal of VirologyOpen Access

Characterization of a simian hepatitis A virus (HAV): antigenic and genetic comparison with human HAV

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Population

PA21 strain of hepatitis A virus recovered from a naturally infected captive owl monkey, and reference human…

Comparison

Antigenic and genetic characterization vs Human HAV strain HM175

Design

Preclinical

Authors

EBEdwin A. BrownUniversity of North Carolina at Chapel HillRJRobert W. JansenUniversity of North Carolina at Chapel HillSLStanley M. LemonUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Does not alter human HAV management; leaves open zoonotic potential and need for expanded genotype surveillance in primates.

Structured PICO

P
Population
PA21 strain of hepatitis A virus (HAV) recovered from a naturally infected captive owl monkey, and reference human virus HM175
I
Intervention
Antigenic and genetic characterization (cDNA-RNA hybridization, neutralizing murine monoclonal antibodies, nucleotide sequencing)
C
Comparator
Human HAV strain HM175
O
Outcome
Antigenic similarity and genetic divergence (nucleotide sequence identity)

The PA21 strain of HAV from owl monkeys represents a unique genotype with significant genetic divergence from human HAV despite conserved antigenic structure.

Cite This Study

Brown et al. (1989) studied this question.

synapsesocial.com/papers/6a746cddf5fc394144032358https://doi.org/10.1128/jvi.63.11.4932-4937.1989
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