Key result
Sequence analysis of a new hepatitis A virus isolate from cynomolgus macaques revealed it differs genetically and antigenically from all other sequenced HAVs by about 20% at the nucleotide level.
Cynomolgus macaques are naturally infected by a unique hepatitis A virus strain that differs genetically and antigenically from previously sequenced HAV strains.
Novel macaque HAV strain identified; leaves open zoonotic risk and need for expanded human surveillance.
A new isolate of hepatitis A virus (HAV), CY-145, was isolated from stool specimens obtained from cynomolgus macaques naturally infected with this agent. Sequence analysis of the capsid region of the genome indicated that this virus differed from other sequenced HAV strains by about 20% at the nucleotide level and 7% at the amino acid level. Two amino acid residues (residues 70 of VP3 and 102 of VP1), previously identified as constituting an immunodominant site and conserved in all sequenced HAVs, were changed in the CY-145 virus. Sequence analysis of a second cynomolgus HAV isolate (CY-55), which came from a different geographical location, showed the same amino acid replacement at these two sites. In addition both isolates had an amino acid substitution at the VP3-VP1 cleavage site. These data suggest that the cynomolgus HAV differs genetically and antigenically from all other sequenced HAVs.
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Nainan et al. (1991) studied Hepatitis A virus infection. Sequence analysis of HAV isolates (CY-145 and CY-55) vs. Other sequenced HAV strains was evaluated on Genetic and antigenic differences in the capsid region of the genome. Sequence analysis of a new hepatitis A virus isolate from cynomolgus macaques revealed it differs genetically and antigenically from all other sequenced HAVs by about 20% at the nucleotide level.
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