Key result
Eight weeks of aerobic exercise did not significantly reduce cystatin C (P=0.09) or homocysteine (P=0.07) levels compared to control in inactive, overweight middle-aged women.
Why the study?
Chronic inflammation contributes to atherosclerosis and diabetes, but the effect of aerobic exercise on cystatin C and homocysteine levels in inactive, overweight middle-aged women required investigation.
Does an 8-week aerobic exercise program reduce cystatin C and homocysteine levels in inactive, overweight middle-aged women?
RCT (n=30)
Randomized
No
Does an 8-week aerobic exercise program reduce cystatin C and homocysteine levels in inactive, overweight middle-aged women?
p-value: P=0.09 for cystatin C, P=0.07 for homocysteine
An 8-week aerobic exercise program improved body composition but did not significantly reduce cystatin C and homocysteine levels compared to control in overweight middle-aged women.
Does not support short-term aerobic exercise for these biomarkers; leaves open longer or alternative interventions in overweight women.
Background and Objectives Chronic inflammation is associated with the development of various diseases, including atherosclerosis and diabetes. The aim of this study was to investigate the effect of longterm selected aerobic exercises on changes in cystatin C and homocysteine in inactive and overweight middle-aged women. Subjects and Methods Thirty non-athlete middle-aged women (mean age: 46.06±6.97 years, weight: 71.82±9.11 kg, height: 156.9±5.24 cm, and body mass index: 29.2±4.11kg/m2) voluntarily participated in this project and were randomly divided into the experimental and control groups The experimental group performed selected aerobic exercises (65-75% of maximum heart rate) for eight weeks. Blood samples were taken before and 24 hours after the completion of the research protocol to measure the levels of cystatin C and homocysteine. Analysis of covariance was used for intergroup comparisons and paired t-test was used for intergroup comparisons. Results The results showed that there was no significant difference between the experimental and control groups in cystatin C (P=0.09) and homocysteine (P=0.07) after eight weeks of selected aerobic exercises. A significant decrease was observed in weight (P=0.001) and body mass index (P=0.002) in the experimental group compared to the control group. Conclusion Overall, the results of the present study showed that although the eight-week activity program improved the body composition of overweight middle-aged women, longer periods of aerobic exercise are required to examine clearer biochemical results.
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Porsesh et al. (2022) conducted an RCT in Inactive and overweight (n=30). Aerobic exercise vs. No activity was evaluated on Cystatin C and homocysteine levels (p=P=0.09 for cystatin C, P=0.07 for homocysteine). Eight weeks of aerobic exercise did not significantly reduce cystatin C (P=0.09) or homocysteine (P=0.07) levels compared to control in inactive, overweight middle-aged women.
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