Key result
Opioid-free anesthesia provided similar intraoperative nociception control compared to opioid-based anesthesia in bariatric surgery patients, with no significant difference in maximum NOL values.
Why the study?
To compare the effectiveness of opioid-free anesthesia with Nociception Level Index monitoring against opioid-based anesthesia on intraoperative analgesia, postoperative nausea and vomiting, and antiemetic and analgesic needs in laparoscopic bariatric surgery.
Does opioid-free anesthesia with nociception monitoring reduce postoperative analgesic requirements and nausea/vomiting compared to opioid-based anesthesia in bariatric surgery patients?
RCT (n=40)
Single-blind
According to the order of admission to the operating room
No
Does opioid-free anesthesia with nociception monitoring reduce postoperative analgesic requirements and nausea/vomiting compared to opioid-based anesthesia in bariatric surgery patients?
Absolute Event Rate: 74.5% vs 69.55%
p-value: p=>0.05
Opioid-free anesthesia guided by nociception monitoring is feasible in bariatric surgery and reduces postoperative opioid requirements without compromising intraoperative analgesia.
May warrant opioid-free anesthesia consideration in bariatric surgery; leaves open confirmation via randomized trials.
Aim: In this study, we aimed to compare the effectiveness of an opioid-free anesthesia method with Nociception Level (NOL) Index monitoring to provide intraoperative analgesia control in laparoscopic bariatric surgeries and its effect on the risk of postoperative nausea and vomiting and the need for antiemetics and analgesics with the opioid-based anesthesia.Material and Methods: Forty patients who underwent laparoscopic bariatric surgery were classified into two groups: those who received opioid-based anesthesia (OA) and those who received opioid-free anesthesia (OFA).Intraoperative NOL index values and additional analgesia requirements were noted.Additional analgesia was administered when the postoperative Visual Analogue Scale (VAS) score was ≥3, an antiemetic drug was administered when the nausea-vomiting score was ≥ 2, and their amounts were noted.Results: There were no significant differences between the groups in terms of NOL values (p>0.05) and 0 vs. 0, p>0.05).Similarities were found between intraoperative and postoperative additional analgesia, VAS score, nausea-vomiting score, and antiemetic drug consumption (p>0.05).Tramadol consumption in the first postoperative 24 hours was significantly higher in the OA group (150.0 ± 48.7 mg vs. 110.0± 44.7, p= 0.012).Discussion: Opioid-free anesthesia with intraoperative nociception monitoring can be safely applied in bariatric surgery patients.
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Akman et al. (2023) conducted an RCT in Laparoscopic bariatric surgery (n=40). Opioid-free anesthesia vs. Opioid-based anesthesia (remifentanil) was evaluated on Maximum Nociception Level (NOL) index value (p=>0.05). Opioid-free anesthesia provided similar intraoperative nociception control compared to opioid-based anesthesia in bariatric surgery patients, with no significant difference in maximum NOL values.
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