Independent influence of previous myocardial infarction, renal function and ejection fraction on the severity of heart failure in men

The Goal: Processes of cardiac remodelling, especially collagen deposition and following fibrosis, seen both in infarcted and non-infarcted myocardium are important contributors to the development of the impaired left ventricular (LV) function. The objective of this study was to assess the independent influences of various clinical variables, including previous myocardial infarction (MI), on the severity of heart failure (HF) in men. Patients and Methods: This prospective study included consecutive male patients with acute HF, hospitalized at the Division of Cardiology, Department of Internal Medicine, University Hospital Centre Split. Statistical analysis was performed by means of T-test and linear regression in univariate, and multiple logistic regression in multivariate analysis. The P value of less than 0.05 was considered to be statistically significant.