Key result
Older age is linked to a ~20% 3-year HF hospitalization rate but not LV remodeling.
Why the study?
Following MI, age and LV remodelling both increase adverse event risk, but whether the higher incidence of heart failure in elderly patients stems from a greater propensity for LV remodelling was unknown.
Is the increased incidence of heart failure following anterior myocardial infarction in elderly patients associated with a greater propensity for left ventricular remodelling?
Cohort (n=266)
Is the increased incidence of heart failure following anterior myocardial infarction in elderly patients associated with a greater propensity for left ventricular remodelling?
Older age is a major determinant of heart failure hospitalization after anterior myocardial infarction, but this increased risk is not driven by a greater propensity for left ventricular remodelling.
Supports closer HF monitoring in older patients; leaves open age effects on remodeling pathways.
AIMS: Following myocardial infarction (MI), both age and left ventricular (LV) remodelling are associated with an increased risk of adverse events. We tested the hypothesis that the increased incidence of heart failure following MI in elderly patients is associated with a greater propensity for LV remodelling. METHODS AND RESULTS: We monitored 266 patients with anterior MI. Echocardiographic studies were performed at hospital discharge, at 3 months, and at 1 year following hospitalization for MI. A clinical follow-up examination was performed after 3 years. Left ventricular remodelling was documented by an increase in LV end-diastolic volume after 1 year. Left ventricular end-diastolic and end-systolic volumes did not differ with age for all time points studied. Left ventricular remodelling was observed in 31, 26, 34, and 34% of patients <48, 48-57, 58-71, and >71 years of age, respectively. The 3 year heart-failure hospitalization rates were 1.9, 1.5, 11.0, and 20.3% for patients <48, 48-57, 58-71, and >71 years of age, respectively. Hospitalization for heart failure was more frequent in older patients. CONCLUSION: We found that age was a major determinant of subsequent re-hospitalization for heart failure. However, we found no significant association between age and the LV remodelling process.
No takes yet. Share an insight, caveat, or question.
Ennezat et al. (2008) conducted a cohort in anterior myocardial infarction (n=266). Older age vs. Younger age was evaluated on Left ventricular remodelling at 1 year and hospitalization for heart failure at 3 years. Older age was associated with a higher 3-year rate of heart failure hospitalization (20.3% in patients >71 years vs 1.9% in patients <48 years), but not with left ventricular remodelling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: