March 1, 2014Open Access
Development and course of heart failure after a myocardial infarction in younger and older people.
Key result
Following acute myocardial infarction, the risk of developing heart failure and dying increased progressively with age, with 82% of patients over 75 dying during follow-up compared to 24% under 65.
Population
896 patients with acute myocardial infarction during 1998, categorized by age.
Design
Cohort
Follow-up
From 1998 to December 2005 (approximately 7 years)
Authors
Discussion
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Implication
May warrant closer post-MI monitoring in older adults; leaves open whether targeted interventions reduce HF incidence.
Study Design
Type
Cohort (n=896)
Multicenter
Yes
Structured PICO
P
Population
896 patients with acute myocardial infarction (AMI) during 1998, categorized by age (< 65 years, 65-75 years, and > 75 years).
O
Outcome
Development, course (persistence or resolution) of heart failure, and mortality after acute myocardial infarctionhard clinical
Main Result
Absolute Event Rate: 82% vs 24%
Heart failure is a very common precursor to death following an acute myocardial infarction across all age groups, with incidence and mortality increasing progressively with age.
Limitations
- Substantial changes in management have occurred since 1998, meaning treatments were suboptimal by contemporary standards
- Systematic attempts were not made to withdraw diuretics, which may have overestimated the persistence of heart failure
- A simple, robust definition of heart failure remains elusive, relying on clinical assessment and loop diuretic use
Cite This Study
Torabi et al. (2014) conducted a cohort in Acute myocardial infarction (n=896). Age > 75 years vs. Age < 65 years was evaluated on All-cause mortality. Following acute myocardial infarction, the risk of developing heart failure and dying increased progressively with age, with 82% of patients over 75 dying during follow-up compared to 24% under 65.