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May 9, 2026Cardiology DiscoveryOpen Access

Developing heart failure after AMI is linked to ~73% higher 3-year all-cause mortality.

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Why the study?

Heart failure is a major complication of myocardial infarction that increases morbidity and mortality, but comprehensive epidemiological and clinical data on the Korean population were lacking.

Population

258,916 patients aged ≥ 18 years newly hospitalized for MI between 2010 and 2021 in Korea

Comparison

Patients who developed HF vs those without HF after MI

Design

Nationwide retrospective cohort study

Key result

Developing heart failure after acute myocardial infarction occurred in 14.1% of patients and was associated with a 3-year all-cause mortality of 37.8% versus 21.9% in those without heart failure.

Authors

SJSe-Jun JeonSKSun-Hwa KimMYMin-Jae Yoon

Discussion

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Overview

Highlights substantial post-MI HF burden; hypothesis-generating for prevention trials but should not yet change practice.

Key Points

  • The study aims to evaluate the incidence, risk factors, and long-term outcomes of heart failure after myocardial infarction in the Korean population.
  • Retrospective cohort study using the Korean National Health Insurance Database.
  • Included 258,916 patients aged ≥ 18 hospitalized for myocardial infarction from 2010 to 2021.
  • Cox proportional hazard models identified independent risk factors for heart failure development.
  • 14.1% of patients developed heart failure during follow-up.
  • Cumulative incidence rates of heart failure at 1, 2, and 3 years were 7.2%, 10.2%, and 12.3%, respectively.
  • 3-year cumulative probability of all-cause mortality was 37.8% in heart failure patients compared to 21.9% in those without.

Study Design

Type

Cohort (n=258,916)

Multicenter

Yes

Structured PICO

P
Population
258,916 patients aged ≥ 18 years newly hospitalized for acute myocardial infarction between 2010 and 2021 in Korea, excluding those with a history of MI or HF within the previous 3 years.
O
Outcome
Incidence of heart failure and all-cause mortalityhard clinical

Main Result

Absolute Event Rate: 37.8% vs 21.9%

Heart failure is a frequent complication following acute myocardial infarction in the Korean population, occurring in 14.1% of patients and significantly increasing the 3-year risk of all-cause mortality.

Cite This Study

Jeon et al. (2026) conducted a cohort in Acute Myocardial Infarction (n=258,916). Heart failure development after MI vs. No heart failure development was evaluated on 3-year cumulative probability of all-cause mortality. Developing heart failure after acute myocardial infarction occurred in 14.1% of patients and was associated with a 3-year all-cause mortality of 37.8% versus 21.9% in those without heart failure.

synapsesocial.com/papers/69fed090b9154b0b828779a1https://doi.org/10.1097/cd9.0000000000000196
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incident heart failure and related outcomes in survivors of acute myocardial infarction within the first year in Sweden across 25 years, between 1997 and 20222025 · 1 citations
  2. 2The timing of development and subsequent clinical course of heart failure after a myocardial infarction2008 · 134 citations
  3. 3Declining In-Hospital Mortality and Increasing Heart Failure Incidence in Elderly Patients With First Myocardial Infarction2008 · 369 citations
  4. 4Characteristics, Outcomes and Predictors of Long-Term Mortality for Patients Hospitalized for Acute Heart Failure: A Report From the Korean Heart Failure Registry2011 · 124 citations
  5. 5Prognostic Impact of In‐Hospital and Postdischarge Heart Failure in Patients With Acute Myocardial Infarction: A Nationwide Analysis Using Data From the Cardiovascular Disease in Norway (CVDNOR) Project2017 · 37 citations