Key result
Left ventricular remodeling after a first myocardial infarction was associated with a significantly increased risk of cardiovascular death or heart failure hospitalization (HR 2.52).
Why the study?
Does left ventricular remodeling (≥20% increase in LVEDV) predict cardiovascular death or heart failure hospitalization in patients with a first anterior MI receiving modern secondary prevention?
Cohort (n=441)
Yes
Does left ventricular remodeling (≥20% increase in LVEDV) predict cardiovascular death or heart failure hospitalization in patients with a first anterior MI receiving modern secondary prevention?
Hazard Ratio: 2.52 (95% CI 1.45–4.36)
p-value: p=0.0007
In the modern era of post-MI management with high rates of evidence-based therapies, left ventricular remodeling remains a strong independent predictor of long-term heart failure hospitalization and cardiovascular death.
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LVR after anterior MI signals higher HF and death risk despite optimal prevention; leaves open whether remodeling is a modifiable target.
Bauters et al. (2017) conducted a cohort in First anterior myocardial infarction (n=441). Left ventricular remodeling (≥20% increase in end-diastolic volume at 1 year) vs. No left ventricular remodeling (<20% increase in end-diastolic volume) was evaluated on Cardiovascular death or hospitalization for heart failure (HR 2.52, 95% CI 1.45-4.36, p=0.0007). Left ventricular remodeling after a first myocardial infarction was associated with a significantly increased risk of cardiovascular death or heart failure hospitalization (HR 2.52).
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