Key result
Adenosine receptor agonists and antagonists show potential in preclinical studies to limit cardiac remodeling, improve cardiac function, and prevent arrhythmias after myocardial infarction.
Why the study?
Current treatments for post-myocardial infarction chronic heart failure and arrhythmias are mainly symptomatic and frequently not satisfactorily effective, highlighting the need to evaluate adenosine receptor modulators targeting cardiac remodeling.
Adenosine receptor modulators represent a promising therapeutic target for preventing post-myocardial infarction cardiac remodeling, heart failure, and arrhythmias, though current evidence is largely limited to animal models.
Requires clinical validation before use; leaves open translation of adenosine modulation to post-MI outcomes in humans.
For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use the compound in the treatment of myocardial infarction. Adenosine exhibits many other effects, as well, which can be helpful in treating complications of myocardial infarction. Over the last decade, the results of over a dozen studies conducted on animal models evaluating the possibility of using adenosine receptor agonists and antagonists in the prevention and treatment of chronic heart failure and arrhythmias after myocardial infarction have been published. This is particularly important in view of the increasing number of patients suffering from such complications, associated with increased survival rates among patients due to advancements in diagnosis and treatment of myocardial infarction itself. Current treatments for chronic heart failure and arrhythmias are mainly symptomatic and frequently are not satisfactorily effective. Cardiac remodeling, an important mechanism behind the pathogenesis of post-myocardial infarction heart failure and arrhythmias, is a promising therapeutic target. This review presents current reports on the use of adenosine receptor agonists and antagonists as modulators of cardiac remodeling in post-myocardial infarction heart failure and arrhythmias.
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Puchałowicz et al. (2019) conducted a review in Post-myocardial infarction heart failure and arrhythmias. Adenosine receptor agonists and antagonists was evaluated. Adenosine receptor agonists and antagonists show potential in preclinical studies to limit cardiac remodeling, improve cardiac function, and prevent arrhythmias after myocardial infarction.
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