Key result
Type 2 diabetes mellitus in adult males was associated with a significant decline in FVC, FEV1, FEF25-75%, and PEFR compared to healthy controls, suggesting a restrictive pulmonary disorder.
Why the study?
Diabetes mellitus affects multiple organs including the lung, prompting evaluation and comparison of pulmonary functions between adult male type 2 diabetic patients and healthy adult male subjects.
Does type 2 diabetes mellitus affect pulmonary functions in adult males compared to healthy subjects?
Case-Control (n=200)
No
Does type 2 diabetes mellitus affect pulmonary functions in adult males compared to healthy subjects?
Type 2 diabetes mellitus is associated with decreased pulmonary function indicative of a restrictive pulmonary disorder in adult males.
May support lung function monitoring in T2DM men; hypothesis-generating and requires prospective confirmation before practice change.
Background: Diabetes mellitus is a multi-system disorder that affects many organs of the bodyincluding the lung. Thus, the lung is considered a 'target organ' in diabetes mellitus. Thepresent study is undertaken to evaluate the impact of type 2 diabetes mellitus onpulmonary functions of adult male diabetic patients and to compare between type 2diabetes mellitus patients and healthy adult male subjects. Methods: Hundred adult male type 2 diabetic patients were selected from the diabetic clinic, Prathima Institute of Medical Sciences, Nagunur, Karimnagar, and 100 adult male healthy subjects were selected randomly among the general population from Karimnagar city. spirograms were recorded by Spirowin PC-basedSpirometer. Parameters such as Forced Vital Capacity (FVC), Forced ExpiratoryVolume in 1st second (FEV1), the ratio of FEV1/FVC, Forced Expiratory Flow (FEF) inthe Middle Half of FVC, and Peak Expiratory Rate (PEFR) were assessed and analyzedby using the paired t-test and ANOVA. Results: Diabetes mellitus has a negative impact on pulmonary functions when compared with healthy subjects. In this study type 2 diabetes mellitus patients showed a significantly greater percentage decline in FVC, FEV1, FEF25-75%, PEFR, and a slight increase in the ratio of FEV1/FVC suggestive of the restrictive pulmonary disorder. Conclusion: This study found the pulmonary functions FVC, FEV1, FEF25%-75%, and PEFR are decreased inType 2 diabetes mellitus compared to controls. FEV1/FVC% slightly increased in Type 2 diabetes mellitus, which is indicative of the restrictive pulmonary disorder
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Rajesh Singh Gautam (2021) conducted a case-control in Type 2 diabetes mellitus (n=200). Type 2 diabetes mellitus vs. Healthy subjects was evaluated on Pulmonary functions (FVC, FEV1, FEV1/FVC, FEF25-75%, PEFR). Type 2 diabetes mellitus in adult males was associated with a significant decline in FVC, FEV1, FEF25-75%, and PEFR compared to healthy controls, suggesting a restrictive pulmonary disorder.
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