Population
Theoretical model of two coupled cells and a multicellular fiber model based on Courtemanche kinetics
Design
Preclinical
Authors
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Electrotonic coupling warrants no clinical action yet; leaves open its contribution to human arrhythmia triggers.
Electrotonic coupling between cardiomyocytes and fibroblasts with altered sodium current properties can generate spontaneous pacemaker activity, potentially serving as a focal trigger for arrhythmias such as atrial fibrillation.
Vincent Jacquemet (2006) studied this question.
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