Key result
An externally applied magnetic field improved haemodynamic perturbations in human coronary artery models by lowering viscosity and decreasing ALWSS, though it increased maximum wall shear stress.
Why the study?
Does a static magnetic field improve haemodynamic perturbations in atherosclerotic coronary arteries?
Does a static magnetic field improve haemodynamic perturbations in atherosclerotic coronary arteries?
An externally applied magnetic field can improve haemodynamic perturbations in human coronary arteries, especially in moderate-to-severe stenosis, though it may increase maximum wall shear stress.
Magnetic fields should not alter practice based on models alone; leaves open their haemodynamic effects for in vivo validation.
Haemodynamic perturbations including elevated blood viscosity, low and oscillatory shear stress are understood to be important pathogenic mediators in atherosclerosis. These haemodynamic abnormalities are influenced by the presence of a magnetic field. This study conducted computational fluid dynamics (CFD) analysis in 4 coronary artery models, derived from authentic human coronaries, with mild and moderate and severe stenosis severity. The aim was to investigate the effect of a static magnetic field of varying intensities on blood viscosity, areas of low wall shear stress (ALWSS), maximum wall shear stress (MWSS) and length and volume of flow recirculation zones. The results showed that the magnetic field results in both beneficial and detrimental changes in haemodynamics. The beneficial effects are lowered viscosity, decreased size of ALWSS and flow recirculation zones whereas the detrimental effect is increased MWSS. With increasing stenosis severity the effect of magnetic field becomes more prominent. An externally applied magnetic field can improve haemodynamics perturbations in human coronary arteries, especially in the setting of moderate-to-severe stenosis severity.
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Javadzadegan et al. (2018) studied Atherosclerotic coronary arteries (n=4). Static magnetic field was evaluated on Blood viscosity, areas of low wall shear stress (ALWSS), maximum wall shear stress (MWSS), and length and volume of flow recirculation zones. An externally applied magnetic field improved haemodynamic perturbations in human coronary artery models by lowering viscosity and decreasing ALWSS, though it increased maximum wall shear stress.
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