April 1, 2001Journal of Biological ChemistryOpen Access

Cooperative Activation by GATA-4 and YY1 of the Cardiac B-type Natriuretic Peptide Promoter

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Population

Cardiac and other GATA-containing cells (preclinical model)

Design

Preclinical

Authors

SBSuparna BhallaMount Saint Mary College LRLynda RobitailleCincinnati Children's Hospital Medical Center MNMona NemerPediatric / Congenital Cardiology

Discussion

Member takes

Implication

Hypothesis-generating for BNP transcriptional control in cardiac stress; leaves open any therapeutic relevance in human heart failure.

Structured PICO

Population

Cardiac and other GATA-containing cells (preclinical model)

Intervention

YY1 and GATA-4 cooperative interaction

Outcome

BNP transcription activationsurrogate

This study identifies YY1 as a transcriptional activator of the BNP gene that works synergistically with GATA-4, providing insight into the molecular regulation of a major cardiac secretory product.

Cite This Study

Bhalla et al. (2001) studied this question.

synapsesocial.com/papers/6a7479e001b447f0dadbd755 https://doi.org/10.1074/jbc.m100208200

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Cooperative Activation by GATA-4 and YY1 of the Cardiac B-type Natriuretic Peptide Promoter

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cooperative Activation by GATA-4 and YY1 of the Cardiac B-type Natriuretic Peptide Promoter

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider