The Stability and Repeatability of Spontaneous Sympathetic Baroreflex Sensitivity in Healthy Young Individuals
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Key result
Spontaneous sympathetic baroreflex sensitivity measures demonstrated moderate stability between two 5-minute recording periods in healthy young adults (intra-class correlation r=0.61-0.63 for burst incidence).
Population
84 healthy young individuals aged 18-31 years, who did not smoke or take regular medication and had no…
Design
Cohort
Authors
Discussion
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Implication
Moderate stability supports brief recordings for research on sympathetic baroreflex sensitivity; leaves open clinical validation in broader populations.
Study Design
Type
Observational (n=84)
Multicenter
No
Structured PICO
P
Population
84 healthy young adults aged 18 to 31 years underwent continuous physiological recordings to evaluate the stability and repeatability of spontaneous sympathetic baroreflex sensitivity.
E
Exposure
Continuous measurements of blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) recorded for 10 minutes (analyzed as two 5-minute periods and a 2-minute segment), with a subgroup of 13 participants repeating measurements on a separate day.
O
Outcome
Stability and repeatability of spontaneous sympathetic baroreflex sensitivity (BRS) quantified using MSNA burst incidence (BRSinc) and total MSNA (BRStotal) within an experimental session and between separate sessions.surrogate
Main Result
Effect estimate: r = 0.63 (males), r = 0.61 (females)
Measures of spontaneous sympathetic baroreflex sensitivity are moderately stable and repeatable within and between testing sessions in healthy young adults, provided the same recording length is used.
Limitations
- Small sample size for the between-day repeatability subgroup (n=13)
- Lack of significant BRS slopes in some individuals during 2-minute recordings due to insufficient blood pressure range
- Potential influence of non-baroreflex inputs such as respiration on MSNA burst amplitude
Cite This Study
Hissen et al. (2018) conducted an observational in Healthy (n=84). Spontaneous sympathetic baroreflex sensitivity assessment was evaluated on Stability of sympathetic BRSinc between first and second 5-min periods (r = 0.63 (males), r = 0.61 (females)). Spontaneous sympathetic baroreflex sensitivity measures demonstrated moderate stability between two 5-minute recording periods in healthy young adults (intra-class correlation r=0.61-0.63 for burst incidence).
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