Why the study?
Does pregnancy or thyroxine administration alter left ventricular structural dimensions in WKY and SHR rats?
Does pregnancy or thyroxine administration alter left ventricular structural dimensions in WKY and SHR rats?
The rat left ventricle can rapidly alter its luminal design and wall mass in response to hemodynamic interventions, with differing responses between normotensive and hypertensive models.
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Differential LV remodeling by strain in rat pregnancy and hyperthyroidism leaves open translation to humans; supports targeted preclinical models.
Friberg et al. (1985) studied this question.
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