Key result
Immobilized anti-LILRB2 antibodies induced more potent activation of LILRB2 than Angptl2, enabling a new serum-free culture approach for the ex vivo expansion of repopulating human cord blood HSCs.
Elucidation of the Angptl2-LILRB2 binding motif enables a new approach for ex vivo expansion of human hematopoietic stem cells using immobilized anti-LILRB2 antibodies.
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May enable serum-free HSC expansion; leaves open clinical translation from animal models.
Deng et al. (2014) studied Ex vivo expansion of hematopoietic stem cells. Immobilized anti-LILRB2 antibodies vs. Angptl2 was evaluated on Activation of LILRB2 and ex vivo expansion of human cord blood HSCs. Immobilized anti-LILRB2 antibodies induced more potent activation of LILRB2 than Angptl2, enabling a new serum-free culture approach for the ex vivo expansion of repopulating human cord blood HSCs.
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