Key result
Angptl2 binding to LILRB2 provides a theoretical basis for ex vivo expansion of human hematopoietic stem cells, while placenta growth factor links iron overload to pulmonary hypertension in sickle cell disease.
Provides a theoretical basis for Angptl2-driven ex vivo expansion of human hematopoietic stem cells.
In this issue of Blood, Deng et al have clarified the molecular mechanism critical for the angiopoietin-like 2 (Angptl2) binding to its receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), providing a theoretical basis for Angptl2-driven ex vivo expansion of human hematopoietic stem cells (HSCs).(1)
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Yoshiaki Kubota (2014) conducted an editorial in Hematologic malignancies and Sickle cell disease. Angptl2 and Placenta growth factor (PlGF) was evaluated. Angptl2 binding to LILRB2 provides a theoretical basis for ex vivo expansion of human hematopoietic stem cells, while placenta growth factor links iron overload to pulmonary hypertension in sickle cell disease.