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January 1, 2014Expert Reviews in Molecular Medicine

Angiopoietin-like-2: a multifaceted protein with physiological and pathophysiological properties

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Key result

Angiopoietin-like-2 is a multifaceted protein with beneficial physiological properties and deleterious pro-inflammatory effects that contribute to chronic diseases, making it a therapeutic target.

Design

Review

Authors

NTNathalie Thorin‐TrescasesMontreal Heart InstituteÉTÉric ThorinMontreal Heart Institute

Discussion

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Overview

ANGPTL2 modulation merits cautious preclinical pursuit in chronic disease; leaves open clinical translation pending targeted trials.

PICO

E
Exposure / Comparator
Angiopoietin-like-2 (Angptl2)

Angptl2 is a multifaceted protein with both beneficial physiological roles and deleterious pro-inflammatory properties contributing to chronic diseases, making it a potential therapeutic target.

Cite This Study

Thorin‐Trescases et al. (2014) reported a review. Angiopoietin-like-2 (Angptl2) was evaluated. Angiopoietin-like-2 is a multifaceted protein with beneficial physiological properties and deleterious pro-inflammatory effects that contribute to chronic diseases, making it a therapeutic target.

synapsesocial.com/papers/6a930d86e94b7197b64aa719https://doi.org/10.1017/erm.2014.19
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiopoietin‐Like 2 Promotes Atherogenesis in Mice2013 · 65 citations
  2. 2Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases2010 · 153 citations
  3. 3Lack of Angiopoietin‐Like‐2 Expression Limits the Metabolic Stress Induced by a High‐Fat Diet and Maintains Endothelial Function in Mice2014 · 20 citations
  4. 4Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer2014 · 12 citations
  5. 5Angiopoietin-Like Protein 2 Induced by Mechanical Stress Accelerates Degeneration and Hypertrophy of the Ligamentum Flavum in Lumbar Spinal Canal Stenosis2014 · 52 citations