Key result
Elevated visceral fat area was significantly associated with a higher risk for subclinical left ventricular systolic dysfunction (OR 5.21; 95% CI 1.76-15.47; P=0.003).
Why the study?
Adipose tissue may contribute to heart failure with normal LVEF, and left ventricular global longitudinal strain detects subclinical systolic dysfunction that predicts cardiovascular events.
Is visceral fat associated with subclinical left ventricular systolic dysfunction in subjects with normal LVEF?
Cross-Sectional (n=954)
No
Is visceral fat associated with subclinical left ventricular systolic dysfunction in subjects with normal LVEF?
Visceral fat, but not subcutaneous fat, is independently associated with impaired global longitudinal strain and subclinical left ventricular systolic dysfunction in individuals with normal LVEF.
Visceral fat assessment may aid early LV risk detection; leaves open causality and intervention effects.
Objective: Adipose tissue may play a role in the pathophysiology of patients with heart failure with normal left ventricular ejection fraction (LVEF). Recent studies have shown that left ventricular (LV) global longitudinal strain (GLS) can detect subclinical LV systolic dysfunction in individuals with normal LVEF, and that such dysfunction strongly predicts future cardiovascular events. We therefore investigated visceral fat and subcutaneous fat would be associated, independently of body mass index, with GLS and cardiac structure in Chinese subjects with normal LVEF. Design and method: The study subjects were recruited from Danyang, a city of Jiangsu Province in 2017. Visceral fat area was measured by dual bioelectrical impedance analysis using Dual Scan and natural logarithmically transformed for statistical analysis. GLS was measured by the 2-dimensional speckle tracking method using GE Vivid E9 system. Results: The 954 study participants (mean age = 54.3 ± 9.0 years) included 373 men (39.1%), 96 obese (10.1%), hypertensive (40.8%), and 70 diabetic patients (7.3%). Visceral fat area was higher in men than women (93.5 vs 62.8 cm2, P < 0.001). GLS was lower in men than women (20.1% vs 21.7%, P < 0.001). In multiple regression analyses, visceral fat was significantly negatively associated with GLS (standard β = -19.0%; P < 0.001) but not with cardiac structure. In multivariable logistic regression analyses, elevated visceral fat area was significantly associated with higher risks for subclinical LV systolic dysfunction (OR = 5.21; 95% CI 1.76–15.47; P = 0.003). Conclusions: Visceral fat, but not subcutaneous fat, is negatively associated with GLS and accordingly associated with a higher risk for subclinical LV systolic dysfunction.
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Liu et al. (2019) conducted a cross-sectional in Normal left ventricular ejection fraction (n=954). Elevated visceral fat area vs. Lower visceral fat area was evaluated on Subclinical LV systolic dysfunction (OR 5.21, 95% CI 1.76-15.47, p=0.003). Elevated visceral fat area was significantly associated with a higher risk for subclinical left ventricular systolic dysfunction (OR 5.21; 95% CI 1.76-15.47; P=0.003).
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