Why the study?
Does tamoxifen withdrawal improve severe hyperlipoproteinemia in a patient with breast cancer?
Population
61-year-old woman with breast cancer treated with tamoxifen (n=1)
Comparison
Tamoxifen withdrawal vs Tamoxifen treatment (baseline)
Design
Case_report
Authors
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May alert clinicians to reversible tamoxifen-associated hypertriglyceridemia on withdrawal; leaves open confirmation beyond this case report.
Does tamoxifen withdrawal improve severe hyperlipoproteinemia in a patient with breast cancer?
Tamoxifen can induce severe, reversible hypertriglyceridemia in some patients, likely by reducing the activities of lipoprotein lipase and hepatic triglyceride lipase.
Brun et al. (1986) studied this question.
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