Cancer—A Major Cardiac Comorbidity With Implications on Cardiovascular Metabolism
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Key result
Cancer and cardiovascular diseases share concurrent metabolic alterations and signaling pathways, which mediate a direct maladaptive crosstalk leading to cachexia and cardiac dysfunction.
Why the study?
Cancer biology may directly affect the heart beyond cardiotoxic chemotherapy side effects, with emerging interest in the metabolic crosstalk between cancer and heart failure.
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Implication
Suggests cancer biology may affect cardiac metabolism; leaves open mechanisms and clinical relevance pending prospective data.
PICO
P
Population
Cancer and Cardiovascular Disease
Cancer and heart failure share concurrent metabolic alterations and inflammatory pathways that mediate a maladaptive crosstalk, contributing to cardiac wasting and increased mortality.
Limitations
- Few studies investigate metabolomic alterations in patient plasma before, during, or after oncological disease.
- Whether specific metabolomic alterations associate with an increased risk for cardiac complications needs further evaluation.
Cite This Study
Finke et al. (2021) conducted a review in Cancer and Cardiovascular Disease. Cancer and cardiovascular diseases share concurrent metabolic alterations and signaling pathways, which mediate a direct maladaptive crosstalk leading to cachexia and cardiac dysfunction.
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