Key result
Tumor-induced systemic metabolic changes, particularly in lipid metabolism, contribute to cardiovascular remodeling and increased cardiovascular risk in cancer patients.
Why the study?
Cardiac metabolic homeostasis is challenged by the increased metabolic demands of proliferating cancer cells, complicating the bidirectional relationship between metabolism and cardiovascular diseases.
This review highlights the systemic metabolic impact of tumors on cardiovascular remodeling and the potential for metabolic metabolites as diagnostic and prognostic signals in cardio-oncology.
Supports metabolic profiling for CV risk assessment in cancer; leaves open whether targeting lipid pathways alters outcomes.
PURPOSE OF REVIEW: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells. RECENT FINDINGS: Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk. Metabolites serve as signals which provide insights for diagnosis and prognosis in cardio-oncology patients. SUMMARY: Metabolic processes demonstrate a complex relationship between cancer cell states and cardiovascular remodeling with potential for therapeutic interventions.
No takes yet. Share an insight, caveat, or question.
Figueiredo et al. (2024) conducted a review in Cancer and cardiovascular diseases. Tumor-induced metabolic changes was evaluated. Tumor-induced systemic metabolic changes, particularly in lipid metabolism, contribute to cardiovascular remodeling and increased cardiovascular risk in cancer patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: