Key result
Zinc/alogliptin combination restored testicular weight, functions, sperm characteristics, and antioxidant defenses in rats with doxorubicin-induced testicular toxicity compared to either drug alone.
Why the study?
Does a zinc/alogliptin combination prevent doxorubicin-induced testicular toxicity in male Wistar rats?
Population
60 male Wistar rats with doxorubicin (DOX)-induced testicular toxicity
Comparison
Zinc and alogliptin combination vs Control, DOX alone, DOX + Zinc alone, DOX +…
Design
Preclinical, Divided into 6 equal groups
Authors
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Hypothesis-generating for fertility preservation during doxorubicin therapy; leaves open translation to clinical trials.
Does a zinc/alogliptin combination prevent doxorubicin-induced testicular toxicity in male Wistar rats?
The combination of zinc and alogliptin may represent a promising therapeutic modality for ameliorating doxorubicin-induced testicular toxicity.
Ahmed M. Kabel (2017) studied Doxorubicin-induced testicular toxicity (n=60). Zinc/alogliptin combination vs. Doxorubicin alone, doxorubicin + zinc, doxorubicin + alogliptin, control was evaluated on Testicular weight, functions, sperm characteristics, and antioxidant defenses. Zinc/alogliptin combination restored testicular weight, functions, sperm characteristics, and antioxidant defenses in rats with doxorubicin-induced testicular toxicity compared to either drug alone.
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