What is the clinical evidence from this study?

Study design: RCT. Population: doxorubicin-induced testicular toxicity (n=25). Intervention: quercetin and sitagliptin vs. doxorubicin alone and negative control. Primary outcome: testosterone, LH, FSH, ALP, LDH, GPx, and TAOC levels.

What does this research mean for the field?

The combination of quercetin and sitagliptin attenuates doxorubicin-induced testicular toxicity in rats by restoring antioxidant capacity and increasing testosterone and FSH levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 2019Drug Design Development and TherapyOpen Access

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

View Full Paper

Ask AI

Bookmark

Key result

Quercetin plus sitagliptin increases testosterone and FSH while restoring GPx in rats with doxorubicin toxicity.

n=25

Why the study?

The effect of quercetin and/or sitagliptin on doxorubicin-induced testicular toxicity was evaluated to explore potential therapeutic options.

Does quercetin and/or sitagliptin prevent doxorubicin-induced testicular toxicity in male Wistar rats?

Comparison

Quercetin and/or sitagliptin treatment vs doxorubicin-only and negative control

Design

Randomized controlled preclinical study

Follow-up

21 days

Authors

ZAZheen Aorahman AhmedUniversity of Sulaimani AAAsoo Nihad Abtar HOHemn Hassan OthmanUniversity of Sulaimani

Discussion

Member takes

Implication

May inform preclinical gonadal protection strategies with doxorubicin; hypothesis-generating and should not yet change practice.

Study Design

Type

RCT (n=25)

Randomization

randomly divided

Structured PICO

Does quercetin and/or sitagliptin prevent doxorubicin-induced testicular toxicity in male Wistar rats?

Population

25 male Wistar rats weighing 240±20 g subjected to doxorubicin-induced testicular toxicity and treated for 21 days.

Intervention

Quercetin 80 mg/kg and/or sitagliptin 10 mg/kg orally daily for 21 days, with I.P. doxorubicin 3 mg/kg on days 8, 10, 12, 15, 17, and 19

Comparator

Negative control (0.9% sodium chloride) and doxorubicin-only treated group

Outcome

Testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutathione peroxidase (GPx), total antioxidant capacity (TAOC), and histopathological examination of testes on day 22surrogate

The combination of quercetin and sitagliptin attenuates doxorubicin-induced testicular toxicity in rats, likely via antioxidant and anti-inflammatory mechanisms.

Cite This Study

Ahmed et al. (2019) conducted an RCT in doxorubicin-induced testicular toxicity (n=25). quercetin and sitagliptin vs. doxorubicin alone and negative control was evaluated on testosterone, LH, FSH, ALP, LDH, GPx, and TAOC levels. The combination of quercetin and sitagliptin significantly increased testosterone and FSH levels and restored GPx levels in rats with doxorubicin-induced testicular toxicity.

synapsesocial.com/papers/6ab0d0b11a68cd0cef788ac3 https://doi.org/10.2147/dddt.s222127

View Full Paper

Ask AI

Bookmark

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider