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July 12, 2019Russian Journal of Transplantology and Artificial OrgansOpen Access

The analysis of oauses of bioprosthetio valve dysfunction: the example of «UniLine» bioprosthesis

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Population

1 explanted «UniLine» bioprosthesis from a 56-year-old patient, explanted from the mitral position after 5…

Design

Case_report

Follow-up

5 years (duration of valve functioning)

Key result

Primary tissue failure, calcification, bacterial contamination, and pannus independently contributed to the dysfunction of the explanted 'UniLine' bioprosthetic heart valve.

Authors

ТГТ. В. ГлушковаЕОЕ. А. ОвчаренкоМРМ. А. Резвова

Discussion

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Overview

May inform surveillance of UniLine recipients; hypothesis-generating for bioprosthetic failure mechanisms.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
Analysis of a single 'UniLine' bioprosthetic heart valve explanted from a 56-year-old patient after 5 years in the mitral position due to dysfunction.
E
Exposure
Pathological and structural evaluation using macroscopic examination, light and scanning electron microscopy, and micro-computed tomography (micro-CT).
O
Outcome
Causes of bioprosthetic valve dysfunction (contribution of primary tissue failure, calcification, bacterial contamination, and pannus).surrogate

Primary tissue failure, calcification, bacterial contamination, and pannus independently contribute to the structural dysfunction of bioprosthetic heart valves.

Limitations

  • Analysis limited to a single explanted bioprosthesis
  • The study could not establish a direct relationship between bacterial contamination and calcification processes

Cite This Study

Глушкова et al. (2019) conducted a case report in Bioprosthetic heart valve dysfunction (n=1). UniLine bioprosthesis was evaluated on Causes of bioprosthetic valve dysfunction (pannus, calcification, primary tissue failure, bacterial contamination). Primary tissue failure, calcification, bacterial contamination, and pannus independently contributed to the dysfunction of the explanted 'UniLine' bioprosthetic heart valve.

synapsesocial.com/papers/6a74935db35e02fb15032947https://doi.org/10.15825/1995-1191-2019-2-75-83
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