Why the study?
Does gender influence blood pressure regulation, treatment efficacy, and adverse effect profiles in the management of hypertension?
Does gender influence blood pressure regulation, treatment efficacy, and adverse effect profiles in the management of hypertension?
Gender-specific physiological differences and adverse effect profiles should be considered in the management of hypertension in women, despite similar overall cardiovascular benefits from antihypertensive therapy.
Supports consideration of sex-specific factors when selecting antihypertensives in women; leaves open need for dedicated prospective trials.
The prevalence, impact, and control of hypertension differ between the sexes in the US population. In addition, pregnancy, oral contraceptive use, and menopausal hormone therapy may influence blood pressure regulation in ways that have therapeutic implications for some women. Whether gender should be a significant consideration in the choice of individual antihypertensive drugs continues to be a topic of intense interest and debate. This brief review will discuss recent findings that bear on considerations of gender in the management of hypertension, particularly among older women.
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Oparil et al. (2005) studied this question.
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