Key result
Any positive depression response on a screening questionnaire was associated with a higher rate of developing CHD over 5 years compared to no positive responses (5.6% vs 2.1%, P=0.002).
Why the study?
Does depression, as detected by a simple 3-item questionnaire, predict the development of coronary heart disease in middle-aged women?
Cohort (n=1,454)
Does depression, as detected by a simple 3-item questionnaire, predict the development of coronary heart disease in middle-aged women?
A simple, validated 3-item depression screening questionnaire can significantly predict the 5-year risk of developing coronary heart disease and its risk factors in middle-aged women.
Answers are grounded in this paper and cite their sources.
Positive depression screening flags higher CHD risk in middle-aged women; leaves open whether screening or treatment alters outcomes.
OBJECTIVE: Experimental and clinical data demonstrate a close association between depression and coronary heart disease (CHD). Because no simple depression instrument for use by general practitioners has been shown to predict CHD, the objective of this study was to evaluate whether such a questionnaire could predict CHD. METHODS: The prevalence of CHD and CHD risk factors was assessed in women with depression, measured by a validated three-question depression screening instrument. Among 1,919 participants in the breast arterial calcification and CHD 5-year prospective study, 1,454 women (75.8%) completed a baseline depression inventory. RESULTS: Among the 1,454 women, 72.2% were postmenopausal, and the mean (SD) age at the conclusion of a 5-year prospective study was 61.3 (12.1) years. Among the women with no CHD risk factors at baseline and with one or less positive depression responses compared with those with two or more, 1.6% versus 3.8%, respectively, had at least one CHD risk factor (P = 0.004) by the 5th year of the study. In addition, 2.3% versus 6.0%, respectively, developed CHD (P = 0.005) by the 5th year of the study. Among all women with no positive depression responses compared with those with any positive depression responses, 2.1% versus 5.6%, respectively, had developed CHD by the 5th year of the study (P = 0.002). Finally, more positive depression responses were associated with a greater prevalence of CHD. CONCLUSIONS: In this prospective study, depression-detected by a validated three-item questionnaire-was able to predict those women more likely to develop CHD.
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Schnatz et al. (2011) conducted a cohort in Coronary heart disease (n=1,454). Positive depression responses on a three-item questionnaire vs. No positive depression responses was evaluated on Development of CHD by the 5th year (p=0.002). Any positive depression response on a screening questionnaire was associated with a higher rate of developing CHD over 5 years compared to no positive responses (5.6% vs 2.1%, P=0.002).
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