Recurrent Major Depression Predicts Progression of Coronary Calcification in Healthy Women: Study of Women's Health Across the Nation
Key result
Recurrent major depression was associated with greater progression of coronary artery calcification compared to a single or no episodes (b = 0.09, p = 0.01).
Why the study?
Does recurrent major depression predict the progression of coronary artery calcification in healthy middle-aged women?
Population
149 middle-aged healthy women who reported no heart disease, stroke, or diabetes, enrolled at the Pittsburgh…
Comparison
Recurrent major depression (n=33) vs Single episode or no episode of major depression
Design
Cohort
Follow-up
approximately 2¼ years
Authors
Discussion
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Member takes
Implication
May warrant depression assessment in middle-aged women for CVD risk; leaves open causal role and treatment impact on CAC.
Study Design
Type
Cohort (n=149)
Multicenter
No
Structured PICO
Does recurrent major depression predict the progression of coronary artery calcification in healthy middle-aged women?
P
Population
149 middle-aged healthy women free of heart disease, stroke, or diabetes, followed for approximately 2.25 years.
E
Exposure
Recurrent major depression (n=33)
C
Comparator
Single episode or no episode of major depression
O
Outcome
Progression of coronary artery calcification (CAC) measured by computed tomography on two occasions approximately 2¼ years apartsurrogate
Main Result
Effect estimate: b 0.09
p-value: p=0.01
Recurrent major depression is associated with accelerated progression of coronary artery calcification in healthy middle-aged women, suggesting it is a risk factor for early atherosclerosis progression.
Cite This Study
Matthews et al. (2010) conducted a cohort in Coronary artery calcification (n=149). Recurrent major depression vs. Single or no episodes of major depression was evaluated on Progression of coronary artery calcification (logged difference scores) (b 0.09, p=0.01). Recurrent major depression was associated with greater progression of coronary artery calcification compared to a single or no episodes (b = 0.09, p = 0.01).