Key result
Flecainide reduces Ca2+ spark and wave frequency in intact rat cardiomyocytes via inhibition of the sarcolemmal sodium current rather than direct ryanodine receptor inhibition.
Why the study?
Does flecainide reduce Ca2+ spark and wave frequency in healthy adult rat cardiomyocytes?
Does flecainide reduce Ca2+ spark and wave frequency in healthy adult rat cardiomyocytes?
Flecainide reduces arrhythmogenic Ca2+ waves in cardiomyocytes by inhibiting the sodium current and enhancing NCX-mediated Ca2+ efflux, providing mechanistic insight into its antiarrhythmic properties.
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Suggests Na current inhibition mediates flecainide's Ca2+ wave effects in rats; leaves open translation to human arrhythmias.
Sikkel et al. (2013) studied Healthy adult rat cardiomyocytes. Flecainide vs. baseline / alternative pharmacological agents was evaluated on Ca2+ spark and wave frequency. Flecainide reduces Ca2+ spark and wave frequency in intact rat cardiomyocytes via inhibition of the sarcolemmal sodium current rather than direct ryanodine receptor inhibition.
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