Key result
Electrical storm in failing and infarcted hearts is driven by a complex interplay of sympathetic nerve remodeling and myocardial ion channel alterations, including the upregulation of apamin-sensitive potassium currents.
Electrical storm in structural heart disease is driven by complex electrophysiological and autonomic remodeling, including IKAS upregulation and sympathetic nerve sprouting, offering potential upstream and downstream therapeutic targets.
May identify novel targets for electrical storm; hypothesis-generating and requires prospective validation before clinical adoption.
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Maruyama et al. (2014) conducted a review in Electrical storm, heart failure, myocardial infarction. Autonomic nervous system and ionic channel remodeling was evaluated. Electrical storm in failing and infarcted hearts is driven by a complex interplay of sympathetic nerve remodeling and myocardial ion channel alterations, including the upregulation of apamin-sensitive potassium currents.
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