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April 1, 1959Experimental Biology and Medicine

Mammalian Cell-Virus Relationship. III. Poliovirus Production by Non-primate Cells Exposed to Poliovirus Ribonucleic Acid.

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Population

Non-primate cells in vitro and in vivo

Design

Preclinical

Authors

JHJohn J. HollandKing's College LondonLMLeroy C. McLarenCenters for Disease Control and PreventionJSJerome T. SyvertonRockefeller Foundation

Discussion

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Implication

Non-primate cells can produce infectious poliovirus when exposed to poliovirus RNA without showing cytopathogenic effects or disease.

Structured PICO

P
Population
Non-primate cells in vitro and in vivo
I
Intervention
Exposure to poliovirus RNA
O
Outcome
Production of infectious poliovirus, cytopathogenic effect in vitro, and disease in vivosurrogate

Non-primate cells can produce infectious poliovirus when exposed to poliovirus RNA without showing cytopathogenic effects or disease.

Cite This Study

Holland et al. (1959) studied this question.

synapsesocial.com/papers/6a74a354f2cd31a1fadbddfchttps://doi.org/10.3181/00379727-100-24798
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE MAMMALIAN CELL VIRUS RELATIONSHIP1959 · 212 citations
  2. 2INFECTIVITY OF RIBONUCLEIC ACID FROM POLIOVIRUS IN HUMAN CELL MONOLAYERS1958 · 141 citations
  3. 3Poliovirus susceptibility in cultured cells2006
  4. 4Poliovirus: Growth in Non-Nucleate Cytoplasm1964 · 14 citations
  5. 5Cell-Free, De Novo Synthesis of Poliovirus1991 · 374 citations