Key result
APOA5 variant carriers had a higher postprandial triglyceride AUC after a pure fat load than wild-type carriers (14.01 vs 9.84 mmol*h/l), a difference that disappeared when glucose was added.
Why the study?
Does adding glucose to a fat load suppress postprandial triglyceridemia in carriers of APOA5 variants compared to a pure fat load?
Observational (n=30)
No
Does adding glucose to a fat load suppress postprandial triglyceridemia in carriers of APOA5 variants compared to a pure fat load?
Absolute Event Rate: 14.01% vs 9.84%
p-value: p=0.016
Adding glucose to a fat load suppresses the exaggerated postprandial triglyceridemia observed in carriers of APOA5 variants, highlighting the interaction between genetics and meal composition.
APOA5 genotyping should not guide dietary advice yet; leaves open macronutrient interactions in postprandial lipemia.
Apolipoprotein A-V plays an important role in the determination of plasma triglyceride (TG) concentration. We aimed to determine whether polymorphisms -1131T>C (rs662799) and 56C>G (rs3135506) of the APOA5 gene have an impact on the course of postprandial lipemia induced by a fat load and a fat load with added glucose. Thirty healthy male volunteers, seven heterozygous for the -1131C variant and three for the 56G variant (HT) carriers, and 20 wild-type (WT) carriers underwent two 8-hour tests of postprandial lipemia - one after an experimental breakfast consisting of 75 g of fat and second after a breakfast consisting of 75 g of fat and 25 g of glucose. HT carriers had a higher postprandial response after fat load than WT carriers (AUC TG: 14.01+/-4.27 vs. 9.84+/-3.32 mmol*h/l, respectively, p=0.016). Glucose added to the test meal suppressed such a difference. Heterozygous carriers of the variants of APOA5 (-1131C and 56G) display more pronounced postprandial lipemia after pure fat load than WT carriers. This statistically significant difference disappears when glucose is added to a fat load, suggesting that meal composition modulates the effect of these polymorphisms on the magnitude of postprandial lipemia.
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Zemánková et al. (2017) conducted an observational in Healthy (n=30). APOA5 -1131C and 56G variants vs. Wild-type APOA5 was evaluated on Area under the curve for triglycerides (AUC TG) after a 75 g fat load (p=0.016). APOA5 variant carriers had a higher postprandial triglyceride AUC after a pure fat load than wild-type carriers (14.01 vs 9.84 mmol*h/l), a difference that disappeared when glucose was added.
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