Key result
The APOA5*2 and APOA5*3 haplotypes were associated with a higher area under the curve of total plasma triglycerides compared to the APOA5*1 haplotype (P=0.03) following a fat load test.
Why the study?
Do APOA5*2 and APOA5*3 haplotypes increase postprandial triglyceride response compared to the APOA5*1 haplotype in healthy Caucasian males?
Cross-Sectional (n=88)
Do APOA5*2 and APOA5*3 haplotypes increase postprandial triglyceride response compared to the APOA5*1 haplotype in healthy Caucasian males?
p-value: p=0.03
The APOA5*2 and APOA5*3 haplotypes are associated with an exaggerated postprandial triglyceride response, which may contribute to the increased coronary heart disease risk associated with these alleles.
May link APOA5 variants to postprandial lipemia in healthy males; leaves open CHD risk mediation and clinical utility.
BACKGROUND: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males. DESIGN AND METHODS: Eighty-eight APO E3/3 volunteers [67 with (-1131T and 56C) APOA5*1 haplotype, 12 with (-1131C and 56C) APOA5*2 haplotype, and nine with (-1131T and 56G) APOA5*3 haplotype] underwent a fat load test consisting of the consumption of 1 g of fat per kilogram body weight and 60,000 IU vitamin A. Blood samples were taken at time 0, at every hour until the sixth hour, and at every 2.5 h until the 11th hour. Total plasma cholesterol (C) and TG, and C, TG, apolipoprotein B-100, apolipoprotein B-48, and retinyl palmitate in lipoprotein fractions were determined. RESULTS: Subjects with the APOA5*2 and APOA5*3 haplotypes had a higher area under the curve of total plasma TG (P = 0.03), large TG-rich lipoprotein (TRL)-TG (P = 0.02), small TRL-TG (P = 0.04), small TRL-C (P = 0.04), large TRL-C (P = 0.03), and small apolipoprotein B100 (P = 0.04) than subjects with the APOA5*1 haplotype. CONCLUSIONS: Our findings show that the presence of the APOA5*2 and APOA5*3 haplotypes in the APOA5 gene is associated with a higher postprandial response that could be involved in the higher risk of coronary heart disease associated with the 56G and -1131C alleles.
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Moreno‐Luna et al. (2007) conducted a cross-sectional in Healthy (n=88). APOA5*2 and APOA5*3 haplotypes vs. APOA5*1 haplotype was evaluated on Area under the curve of total plasma TG (p=0.03). The APOA5*2 and APOA5*3 haplotypes were associated with a higher area under the curve of total plasma triglycerides compared to the APOA5*1 haplotype (P=0.03) following a fat load test.
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