Population
Rat mesenteric resistance arteries perfused in situ (n=7 per group)
Comparison
Pharmacological blockade of AT1, AT2, or both… vs Baseline conditions and arterial segments…
Design
Preclinical
Authors
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AT2 blockade impairs flow-induced dilation in animal arteries; hypothesis-generating for endothelial AT2-NO pathways, does not yet inform human practice.
Locally produced angiotensin II participates in flow-induced dilation of resistance arteries through endothelial AT2 receptor activation of NO release.
Matrougui et al. (1999) studied this question.
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