Key result
Intracellular iron homeostasis and iron-dependent ferroptotic cell death play an essential role in doxorubicin-induced cardiotoxicity.
Why the study?
Doxorubicin clinical use is limited by severe dose-dependent cardiotoxicity, and recent discoveries show intracellular iron homeostasis plays an essential role in its mechanisms.
Design
Mini-review
Authors
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Iron homeostasis may guide cardioprotective strategies with doxorubicin; leaves open prospective validation in trials.
Understanding the role of iron and ferroptosis in doxorubicin-induced cardiotoxicity may aid in developing novel drug delivery systems with reduced adverse effects.
Qin et al. (2021) conducted a review in Doxorubicin-induced cardiotoxicity. Doxorubicin was evaluated. Intracellular iron homeostasis and iron-dependent ferroptotic cell death play an essential role in doxorubicin-induced cardiotoxicity.
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