Why the study?
To provide insights and discuss approaches to help clinicians better evaluate changes in right-to-left shunts in patients with patent foramen ovale.
Does 4D flow MRI provide reproducible multilevel and inter-reader quantification of shunt severity in patients with atrial septal defects?
Observational (n=29)
Yes
Does 4D flow MRI provide reproducible multilevel and inter-reader quantification of shunt severity in patients with atrial septal defects?
Effect estimate: r = 0.885-0.991; ICC = 0.96-0.99
4D flow MRI provides highly reproducible, multilevel quantification of blood flow and shunt severity in patients with atrial septal defects, demonstrating its reliability for clinical use across different centers.
Supports reproducible 4D flow MRI shunt quantification in ASD; leaves open prospective validation against catheterization.
Patent foramen ovale (PFO) is a common congenital heart disorder associated with stroke, decompression sickness and migraine. Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiography has important clinical significance and can improve the accuracy of detecting right-left shunts (RLSs) in patients with PFO. In this letter, regarding an original study presented by Yao et al , we present our insights and discuss how to better help clinicians evaluate changes in PFO-related RLS.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2025) conducted an observational in Atrial septal defect (ASD) (n=29). 4D flow MRI vs. Stroke volumes from 4D flow anatomic data was evaluated on Correlation of pulmonary and systemic blood flow measurements at multiple levels and inter-reader agreement (r = 0.885-0.991; ICC = 0.96-0.99).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: