Key result
Contrast-enhanced transcranial Doppler demonstrated a 92.85% sensitivity and 82.35% specificity for identifying patent foramen ovale when compared to transesophageal echocardiography.
Why the study?
Does contrast-enhanced transcranial Doppler accurately detect right-to-left shunt for patent foramen ovale screening compared to transesophageal echocardiography in patients evaluated for PFO?
Cross-Sectional (n=45)
No
Does contrast-enhanced transcranial Doppler accurately detect right-to-left shunt for patent foramen ovale screening compared to transesophageal echocardiography in patients evaluated for PFO?
Contrast-enhanced transcranial Doppler is a highly sensitive and specific screening tool for patent foramen ovale that correlates well with transesophageal echocardiography.
Answers are grounded in this paper and cite their sources.
May support contrast-enhanced TCD for PFO screening; leaves open prospective validation against TEE.
UNLABELLED: Right-to-left shunt (RLS) can be identified by contrast-enhanced transcranial Doppler (cTCD) in patent foramen ovale (PFO) patients. AIM: To evaluate cTCD for PFO screening comparing it to cTEE. METHOD: 45 previous cTCD performed for PFO diagnosis and correlated its findings with cTEE. Patients were submitted to a cTCD standardized technique and were divided in two groups according to RLS: Group 1, patients with a positive RLS and Group 2 when RLS was negative. RESULTS: 29 (65%) patients were included in group 1 and 16 (35%) in group 2. PFO confirmation by cTEE was performed in 28 (62%) patients. cTCD had a 92.85% sensitivity, 82.35% specificity, 89.65% positive predictive value and 87.5% negative predictive value when compared to cTEE for PFO diagnosis. CONCLUSION: Standardized technique cTCD allows for RLS visualization in PFO patients with a good correlation with cTEE and can be used as a screening test before cTEE.
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Lange et al. (2008) conducted a cross-sectional in Suspected patent foramen ovale (stroke or migraine) (n=45). Contrast-enhanced transcranial Doppler (cTCD) vs. Contrast-enhanced transesophageal echocardiography (cTEE) was evaluated on Diagnostic accuracy for patent foramen ovale identification (Sensitivity 92.85%, Specificity 82.35%). Contrast-enhanced transcranial Doppler demonstrated a 92.85% sensitivity and 82.35% specificity for identifying patent foramen ovale when compared to transesophageal echocardiography.
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