Why the study?
Does an SO2-regulated pacemaker improve cardiac output compared to fixed rate stimulation in patients with chronically implanted VVI units?
Does an SO2-regulated pacemaker improve cardiac output compared to fixed rate stimulation in patients with chronically implanted VVI units?
An externally tested SO2-regulated pacemaker increased cardiac output by 18% compared to fixed rate stimulation, suggesting central venous oxygen saturation is a viable parameter for autoregulating pacing rate.
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SO2-regulated pacing may boost output in VVI patients; hypothesis-generating and requires randomized validation before clinical use.
A rate-adjusting pacemaker system is described which uses central venous oxygen saturation (SO2) for the regulation of the pacing rate. This system was tested externally in ten patients with chronically implanted VVI units. There was an average increase in cardiac output of 18% with the SO2-regulated pacemaker as compared to the situation during fixed rate stimulation. Central venous oxygen saturation appears to be an ideal biological parameter for autoregulating the pacing rate. It represents the only sensor suitable for the realization of a closed feedback loop concept.
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Wirtzfeld et al. (1982) studied this question.
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