A 12-Month Comparison of ACE Inhibitor and Ca Antagonist Therapy in Mild to Moderate Essential Hypertension. The GLANT Study.

1,936 analyzed patients with mild to moderate essential hypertension (systolic blood pressure ≥160 mmHg and diastolic blood pressure 90-114 mmHg), mean age 60 years, based in Japan. Key exclusions: history of cerebrovascular disease, myocardial infarction, angina pectoris, or renal impairment (serum creatinine > 2.0 mg/dl).

Delapril (ACE inhibitor) 30-60 mg/day up to a maximum of 120 mg/day for 12 months, with step-up therapy (beta-blocker, diuretic) added if blood pressure reduction was insufficient.

Calcium antagonist (mainly manidipine 46.0% or nifedipine 20.3%) for 12 months, matched by age, blood pressure, and renal function, with step-up therapy added if blood pressure reduction was insufficient.

Incidence of cerebrovascular and cardiovascular events at 12 months.hard clinical