Key result
Antihypertensive therapy plus lifestyle changes cuts clinical events ~31% vs. lifestyle advice alone.
Why the study?
Comparative effectiveness of six antihypertensive interventions for mild hypertension had not been established.
Does antihypertensive drug treatment combined with nutritional-hygienic advice reduce blood pressure and cardiovascular events in adults with mild hypertension compared to nutritional-hygienic advice alone?
Comparison
Five antihypertensive drugs plus nutritional-hygienic advice vs placebo plus nutritional-hygienic advice
Design
Randomized double-blind placebo-controlled clinical trial at four US centers
Follow-up
Average 4.4 years
Authors
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Supports combined drug-lifestyle therapy as initial strategy in mild hypertension; confirms event reduction versus lifestyle intervention alone.
RCT (n=902)
Double-blind
Randomized
Yes
Does antihypertensive drug treatment combined with nutritional-hygienic advice reduce blood pressure and cardiovascular events in adults with mild hypertension compared to nutritional-hygienic advice alone?
Absolute Event Rate: 11.1% vs 16.2%
p-value: p=.03
In patients with mild hypertension, initial drug treatment combined with nutritional-hygienic intervention is more effective than nutritional-hygienic treatment alone in lowering blood pressure and preventing clinical events.
J. D. Neaton (1993) conducted an RCT in Mild hypertension (n=902). Antihypertensive drug treatment (chlorthalidone, acebutolol, doxazosin, amlodipine, or enalapril) plus nutritional-hygienic advice vs. Placebo plus nutritional-hygienic advice was evaluated on Cardiovascular and other clinical events (p=.03). Antihypertensive drug treatment combined with nutritional-hygienic intervention reduced cardiovascular and other clinical events compared to placebo (11.1% vs 16.2%; P=0.03).
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