Patients with hypertriglyceridemia exhibit abnormal apolipoprotein composition in VLDL, characterized by increased apo C-II and C-III and decreased apo B, which may impair hepatic clearance of these particles.
May indicate impaired VLDL clearance in hypertriglyceridemia; hypothesis-generating for apo C-targeted therapies pending prospective studies.
The percentages of apo C-II and C-III proteins in very low density lipoprotein (VLDL) were high in the patients with hypertriglyceridemia (type IIb and IV) when compared with normal control subjects and those of apo A-I, A-II and B proteins were low. Positive correlation was shown between serum VLDL concentration and the percentage of apo C proteins, and the inverse relationship was between VLDL concentration and the percent apo B protein. Consequently, C/B and C/E ratios were higher in these patients than in healthy control.By contrast, there were no significant difference in high density lipoprotein apoprotein composition between normal subjects and the patients with high triglyceride concentration.
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Takeuchi et al. (1985) studied this question.
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