Evaluating atherogenic risk using only HDL cholesterol may be misleading in certain dyslipoproteinemias, especially hypertriglyceridemia, due to altered HDL composition.
Serum apolipoprotein A-I and A-II concentrations were lower in type I hyperlipidemia, LCAT deficiency and sever hepatitis, and higher in cholestasis than in normolipidemics. The discrepancies of serum apolipoprotein A concentrations with high density lipoprotein (HDL) cholesterol were observed in some dyslipoproteinemias, especially in the patients with hypertriglyceridemias.There were some differences in the compositions of HDL among various dyslipoproteinemias. Therefore, the faults may occure, when only one component of HDL, for example HDL cholesterol, is used for the evaluation of serum HDL or atherogenic index.
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Takeuchi et al. (1984) studied this question.
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